Home > Planning Projects for Clinical Trials on Effects of Sustained Reductions in Caloric Intake and Related Dietary Practices in Younger and Older Persons (U01 Clinical Trial Optional)

Planning Projects for Clinical Trials on Effects of Sustained Reductions in Caloric Intake and Related Dietary Practices in Younger and Older Persons (U01 Clinical Trial Optional)

Purpose: The effects of a variety of dietary interventions on aging-related outcomes have been examined in human and animal studies. Caloric restriction (CR) has long been known to extend life span and delay onset of a variety of age-related conditions in many, but not all, animal models. A randomized controlled clinical trial, Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE), in non-obese adults age 51 and under, showed favorable effects of two years of CR on risk factors for aging-related conditions and effects on mechanisms that may influence health span and longevity. However, there remains significant uncertainty about the feasibility of sustaining a longer-term CR intervention (e.g., five years or longer) and about whether the effects of CR, including rates of physiologic aging changes and pre-morbid disease progression, would be amplified or attenuated with the increased duration of CR. The findings of such a longer-term CR trial would be valuable whether or not CR is found to be feasible for a large segment of the population, since they would provide data on the relationship of CR effects on longer-term outcomes to mechanisms that could potentially be targeted by pharmacologic or other strategies.
Receipt Date: Expires: October 1, 2020
Total Awards: NIA intends to commit up to $1.85 million in FY 2021 to fund up to two awards.
Eligibility:

Higher Education Institutions

  • Public/State Controlled Institutions of Higher Education
  • Private Institutions of Higher Education

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

  • Hispanic-serving Institutions
  • Historically Black Colleges and Universities (HBCUs)
  • Tribally Controlled Colleges and Universities (TCCUs)
  • Alaska Native and Native Hawaiian Serving Institutions
  • Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

Nonprofits Other Than Institutions of Higher Education

  • Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
  • Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)

For-Profit Organizations

  • Small Businesses
  • For-Profit Organizations (Other than Small Businesses)

Governments

  • State Governments
  • County Governments
  • City or Township Governments
  • Special District Governments
  • Indian/Native American Tribal Governments (Federally Recognized)
  • Indian/Native American Tribal Governments (Other than Federally Recognized)
  • Eligible Agencies of the Federal Government
  • U.S. Territory or Possession

Other

  • Independent School Districts
  • Public Housing Authorities/Indian Housing Authorities
  • Native American Tribal Organizations (other than Federally recognized tribal governments)
  • Faith-based or Community-based Organizations
  • Regional Organizations
Foreign Institutions
  • Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
  • Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.
  • Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Link: https://grants.nih.gov/grants/guide/rfa-files/RFA-AG-21-016.html?utm_source=dlvr.it&utm_medium=twitter#_Section_II._Award_1https://www.rwjf.org/en/library/funding-opportunities/2019/evidence-for-action-investigator-initiated-research-to-build-a-culture-of-health.html?cid=xtw_rwjf_unpd_ini:evidence4action_dte:20190404