Purpose: The overarching goal of this Funding Opportunity Announcement (FOA) is to promote translation of basic science research into knowledge and tools that can be utilized to provide strong justification for later-phase drug discovery and development efforts in areas relevant to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This includes obesity, diabetes and related aspects of endocrinology and metabolism, digestive diseases, liver diseases, nutrition, kidney and urological diseases, hematology, and specific aspects of cystic fibrosis.Its objective is to stimulate research and technology development to promote the early-stage pharmacological validation of drug targets and accompanying small molecule chemical scaffolds or non-viral biologics that are not currently a focus within the biotechnology and pharmaceutical industries. It is expected that there is significant novelty in either the target, chemical scaffold, or non-viral biologic itself, or in the approaches used to pursue further target validation. It is not intended to support research focused on understanding normal biology, disease processes, or generating lists of putative new targets.

At the end of the project period, a successful project will have provided a significant contribution to the data supporting the validity of modulating a target’s activity for safe, efficacious treatment of a disease using a small molecule or non-viral biologic approach.

Receipt Date: Sept. 25, 2015
Expires: March 8, 2016
Standard NIH receipt dates apply.
Total Awards: Application budgets are not limited, but must reflect the actual needs of the proposed research.

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.

Link: http://grants.nih.gov/grants/guide/pa-files/PAR-13-007.html
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